After more than one year of vaccination against COVID-19, no alarming safety problems were detected with the approved COVID-19 vaccines. The likelihood of problems arising in the long term is extremely low. This statement is based on the extensive experience with other vaccines. This statement is based on the extensive experience with other vaccines. Because of this experience, researchers find that side effects (local reactions such as redness, itching or swelling of the injection site or general reactions such as fever, chills, fatigue, nausea or headache) after vaccination occur during the first days after vaccination. People who participated in the studies will continue to be followed up, often for up to two years after vaccination. The data collected shows that COVID-19 vaccines are very safe. The goal of this follow-up is to monitor the duration of protection and efficacy of the vaccines. The follow-up is in no way an indication that late side effects are expected.